Inhibitors of protein isoprenyl transferases
US6310095A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 1998 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | May 7, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L.sub.2 --, and (i) heterocyclic-L.sub.2 --; R.sub.2 is selected from (a) ##STR2## (b) --C(O)NH--CH(R.sub.14)--C(O)OR.sub.15, ##STR3## (d) --C(O)NH--CH(R.sub.14)--C(O)NHSO.sub.2 R.sub.16, (e) --C(O)NH--CH(R.sub.14)-tetrazolyl, (f) --C(O)NH-heterocyclic, and (g) --C(O)NH--CH(R.sub.14)--C(O)NR.sub.17 R.sub.18 ; R.sub.3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, ##STR4## and --P(W)R.sup.R3 R.sup.R3' ; R.sub.4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L.sub.1 is absent or is selected from (a) --L.sub.4 --N(R.sub.5)--L.sub.5 --, (b) --L.sub.4 --O--L.sub.5 --, (c) --L.sub.4 --S(O).sub.n --L.sub.5 -- (d) --L.sub.4 --L.sub.6 --C(W)--N(R.sub.5)--L.sub.5 --, (e) --L.sub.4 --L.sub.6 --S(O).sub.m --N(R.sub.5)--L.sub.5 --, (f) --L.sub.4 --N(R.sub.5)--C(W)--L.sub.7 --L.sub.5 --, (g) --L.sub.4 --N(R.sub.5)--S(O).sub.p --L.sub.7 --L.sub.5 --, (h) optionally substituted …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.