Process for preparing D-alloisoleucine and intermediates for preparation
US6310242A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 17, 1999 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Feb 17, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C227/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are a novel process for preparing D-alloisoleucine and an improved process for epimerizing L-isoleucine to prepare D-alloisoleucine. In the former process, (2S, 3S)-tartaric acid derivative of formula I below; wherein R stands for a hydrogen atom, a C.sub.1 -C.sub.3 lower alkyl group, lower alkoxy group, chlorine atom, bromine atom and nitro group; and "n" is a number of 0, 1 and 2; is combined with an epimer mixture of L-isoleucine and D-alloisoleucine in a reaction medium to form a complex of D-alloisoleucine and the compound of formula I. The precipitated complex is decomposed by putting it in an alcohol to isolate D-alloisoleucine. In the latter process, L-isoleucine is suspended in an inert solvent which does not substantially dissolve amino acids, and epimerized in the presence of C.sub.1 -C.sub.5 saturated lower fatty acid and salicylaldehyde. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.