Iodinated x-ray contrast media

US6310243A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Torsten Almen · Malmö, SE
• Sven Andersson · Malmö, SE
• Lars-Goran Wistrand · Oslo, NO
• Klaes Golman · Hørsholm, DK
• Oyvind Antonsen · Tvedestrand, NO
• Rune Fossheim · Oslo, NO
• Unni Nordby Wiggen · Rasta, NO
• Hakan Wikstrom · Groningen, NL
• Tomas Klingstedt · Lund, SE
• Ib Luenbach · Dragør, DK
• Arne Berg · Sandvika, NO
• Harald Dugstad · Oslo, NO

Key dates

• Filing date: Dec 22, 1998
• Grant date: Oct 30, 2001
• Expiry date: Dec 22, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C.sub.6 R.sub.6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20.degree. C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20.degree. C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.