Photocleavable and acid cleavable linkers for combinatorial chemistry
US6310244A · kind A · utility
13Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 23, 1998 |
| Grant date | Oct 30, 2001 |
| Priority date | — |
| Expiry date | Jul 23, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/11
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R.sup.1 is --NO.sub.2 or --CHO; R.sup.2 is --OCH.sub.3, --CHO or --H; R.sup.3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3. ##STR1## A substrate of solid phase synthesis of the formula III is also disclosed. ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.