Patent · US Expired

Delivery of nucleic acid materials

US6312727A · kind A · utility

61Cited by

3References

52Claims

0Family size

Inventors

Etienne Schacht · Staden, BE
Leonard Seymour · Birmingham, GB
Karel Ulbrich · Praha, CZ

Key dates

Filing date	May 6, 1999
Grant date	Nov 6, 2001
Priority date	—
Expiry date	May 6, 2019

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/645
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Synthetic polymer-based carrier vehicles for delivery of nucleic acid material to target cells in biological systems are made by self-assembly of the nucleic acid with cationic polymer material so as to condense the nucleic acid and form a polyelectrolyte complex and reacting the complex with hydrophilic polymer material which bonds to the complex forming a hydrophilic coating that stabilizes the complex and provides an outer protective steric shield. The carrier vehicles are useful for gene therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.