Patent · US Expired

Viable contaminant particle free adenoviruses, their prepartion and use

US6312946A · kind A · utility

17Cited by

2References

23Claims

0Family size

Assignee

RHONE-POULENC RORER S.A. · FR

Inventors

Patrice Yeh · Paris, FR
Michel Perricaudet · Rambouillet, FR
Cecile Orsini · Paris, FR

Key dates

Filing date	Apr 22, 1997
Grant date	Nov 6, 2001
Priority date	—
Expiry date	Apr 22, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/002
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Novel adenovirus-derived viral vectors, the preparation thereof, and their use in gene therapy, are disclosed. In particular, recombinant adenoviruses including an adenovirus genome wherein (i) the E1 region is inactivated, (ii) the genomic organization is modified, and (iii) optional recombination with the producing line genome generates non-viable viral particles, are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.