Optical sensor using an immunological reaction and a fluorescent marker
US6312961A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 24, 1999 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | May 24, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A biosensor comprises a waveguide into which light is coupled by a diffraction grating. The sample to be analyzed is placed on a reaction region in which a component of the immunological reaction is provided, for example antibodies or antigens. Fluorescence is excited on the surface of the waveguide because of the presence of a marker for example, a labelled antigen or antibody. Fluorescence is decoupled from the waveguide by the coupling diffraction grating or another diffraction grating. The waveguide is made of a material emitting light when it is excited by the marker excitation beam. This latter emission has a peak wavelength different from that of the emission radiation due to the marker used in the immunological reaction. Waveguide material fluorescence emission provides a reference during measurement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.