Antagonists of calcitonin gene-related peptide

US6313097A · kind A · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Klaus Rudolf · Warthausen, DE
• Wolfhard Engel
• Henri Doods · Warthausen, DE
• Gerhard Hallermayer · Biberach an der Riß, DE

Key dates

• Filing date: Mar 10, 2000
• Grant date: Nov 6, 2001
• Expiry date: Mar 10, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) ##STR1## wherein A, R, R.sup.1, R.sup.2, X.sup.1, X.sup.2, X.sup.3, and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including pharmaceutical compositions containing these compounds, and their use in the selective antagonization of calcitonin gene-related peptide (CGRP) and in the treatment or prophylaxis of migraine or cluster headaches, non-insulin-dependent diabetes mellitus, inflammation, allergic rhinitis, asthma, morphine tolerance, menopausal hot flashes, and diseases characterized by excessive vasodilatation and consequent reduction in blood-flow.