Pectic substance as a growth factor stabilizer
US6313103A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 24, 1998 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | Jul 24, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0045
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pectic substance from Aloe Vera and other sources is used as a stabilizer and a delivery vehicle for pectin/heparin-binding proteins, such as pectin/heparin binding growth factors. Aloe pectin, a naturally occurring LM (low methoxyl) pectin, binds to pectin/heparin-binding growth factors, i.e., bFGF, aFGF, and KGF of fibroblast growth factor (FGF) family and TGF-.beta.1 of transforming growth factor-.beta. (TGF-.beta.) family. Commercial LM or HM (high methoxyl) citrus pectins tested did not exhibit any binding activity with bFGF. A weak binding to bFGF was observed with a de-esterified pectin (polygalacturonic acid) prepared from citrus. The binding protected the growth factor from protease digestion. The calcium gel beads prepared with Aloe pectin also bound to these pectin/heparin-binding growth factors. The growth factor could also be encapsulated in the pectin calcium gel and Aloe pectin sodium gel. Pectin/heparin-binding growth factor stabilized by pectin is used for wound healing. A pectin-containing matrix is used for the isolation of a pectin/heparin-binding protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.