Substituted 1,2,3,4-tetrahydronaphthalene derivatives

US6313118A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Stefan Berg · Ekerö, SE
• Mats Linderberg · Gately Drive, SE
• Svante Ross · Gately Drive, SE
• Seth-Olov Thorberg · Haditha, IQ
• Bengt Ulff · Gately Drive, SE

Key dates

• Filing date: Oct 21, 1998
• Grant date: Nov 6, 2001
• Expiry date: Oct 21, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new piperidyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula I ##STR1## wherein PA1 X is N or CH; PA1 Y is NR.sub.2 CH.sub.2, CH.sub.2 --NR.sub.2, NR.sub.2 --CO, CO--NR.sub.2 or NR.sub.2 SO.sub.2 PA2 wherein R.sub.2 is H or C.sub.1 -C.sub.6 alkyl; PA1 R.sub.1 is H, C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.6 cycloalkyl; R.sub.3 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or (CH.sub.2).sub.n -aryl, PA2 wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted PA1 n is 0-4; PA1 R.sub.9 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, OCF.sub.3, OCHF.sub.2, OCH.sub.2 F, halogen, CN, CF.sub.3, OH, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkyl, NR.sub.6 R.sub.7, SO.sub.3 CH.sub.3, SO.sub.3 CF.sub.3, SO.sub.2 NR.sub.6 R.sub.7, an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C.sub.1 -C.sub.6 alkyl; or COR.sub.8 ; wherein R.sub.6, R.sub.7 and R.sub.8 are as defined above, PA1…