Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression

US6313126A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Richard E. Mewshaw · King of Prussia, US
• Ping Zhou · Plainsboro, US
• Dahui Zhou · Groton, US
• Kristin Meagher · Thousand Oaks, US
• Magda Asselin · Mahwah, US
• Deborah Evrard · Hamilton Square, US
• Adam Matthew Gilbert · Congers, US

Key dates

• Filing date: Dec 30, 1999
• Grant date: Nov 6, 2001
• Expiry date: Dec 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise ##STR1## Wherein: PA1 R.sub.1, R.sub.2 and R.sub.3 are each, independently, hydrogen, halogen, CF.sub.3, alkyl, alkoxy, MeSO.sub.2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; PA1 R.sub.4 is hydrogen, halogen, or alkyl; PA1 R.sub.5 is hydrogen, alkyl, alkylaryl, or aryl; PA1 R.sub.6 is hydrogen, halogen, CF.sub.3, CN, carbamide, or alkoxy; PA1 X.sub.1, X.sub.2 and X.sub.3 are each carbon or one of X.sub.1, X.sub.2 or X.sub.3 may be nitrogen; PA1 Y is carbon or nitrogen; and PA1 Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.