Dithiolin derivatives, their preparation and their therapeutic effect

US6313164A · kind A · utility

Assignee

• Sankyo Holdings Co., Ltd. · JP

Inventors

• Takashi Fujita · Higashiomi, JP
• Tomihisa Yokoyama · Saitama, JP

Key dates

• Filing date: Jul 15, 1999
• Grant date: Nov 6, 2001
• Expiry date: Jul 15, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R.sup.1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an optionally substituted alkyl group; A is a single bond, an oxygen atom, a carbonyl group or a group of the formula --N(R.sup.2)CO--, --N(R.sup.2)CS--, --N(R.sup.2)SO.sub.2 --, --CON(R.sup.2)N(R.sup.3)CO--, --CON(R.sup.2)CO--, --CON(R.sup.2)CS--, --CON(R.sup.2)SO.sub.2 --, --O--CO--, --ON(R.sup.2)CO--, --ON(R.sup.2)SO.sub.2 --, --O--CON(R.sup.2)N(R.sup.3)CO--, --O--CON(R.sup.2)CO--, --O--CON(R.sup.2)SO.sub.2 --, --CO--O--, --CO--CO--, --CO--CON(R.sup.2)N(R.sup.3)CO--, --CO--CON(R.sup.2)CO--, --CO--CON(R.sup.2)SO.sub.2 --, --N(R.sup.2)O--, --N(R.sup.2)COCO--, --N(R.sup.2)N(R.sup.3)CO--, --N(R.sup.2)N(R.sup.3)SO.sub.2 --, --N(R.sup.2)CON(R.sup.3)N(R.sup.4)CO--, --N(R.sup.2)CON(R.sup.3)CO--, --N(R.sup.2)CON(R.sup.3)SO.sub.2 -- or --N(R.sup.2)CON(R.sup.3)SO.sub.2 N(R.sup.4)CO--, wherein R.sup.2, R.sup.3 and R.sup.4 are the same or different and each is hydrogen, alkyl, aralkyl, acyl or a substituent .alpha.; B is a single bond, or a group of the formula --N(R.sup.5)-- or --N(R.sup.6)N(R.sup.5)-- wh…