Photoactivation of proteins for conjugation purposes
US6313274A · kind A · utility
7Cited by
13References
42Claims
0Family size
Inventors
Key dates
| Filing date | May 25, 1995 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | May 25, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/815
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A protein containing one or more disulfide bonds, e.g., an antibody, is subjected to ultraviolet radiation to reduce one or more such bonds to reactive sulfhydryl groups; the resulting photoactivated protein is reacted with other chemical entity which is reactive with sulfhydryl, such as certain radiometals, chelating agents, drugs and toxins, so as to obtain a conjugate useful in, e.g., in vitro diagnosis, in vivo imaging, and therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.