Human endothelin receptor
US6313276A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1993 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | Sep 14, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
DNA encoding an endothelin receptor shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. In the Sequence Listing is isolated from cDNA which is prepared from poly(A).sup.+ RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 and SEQ ID NO: 2 is an ET.sub.A -receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 3 and SEQ ID NO: 4 is an ET.sub.B -receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.