Purification process

US6313289A · kind A · utility

Assignee

• Biochemie Gesellschaft m.b.H · AT

Inventors

• Johannes Ludescher · Feldbach, AT
• Ludwig Miller · Innsbruck, AT
• Hubert Sturm · Innsbruck, AT
• Werner Veit · Unterhaching, DE
• Martin Decristoforo · Brixlegg, AT
• Siegfried Wolf · Brixlegg, AT

Key dates

• Filing date: Aug 4, 1999
• Grant date: Nov 6, 2001
• Expiry date: Aug 4, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D501/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Crystalline 2-(amninothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephe m-4-carboxylic acid with an amine of formula N(R.sub.1)(R.sub.2)(R.sub.3), wherein R.sub.1, R.sub.2, and R.sub.3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-ceph em-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.