Base-catalyzed synthesis of 1-aryl-4-(aryl ethyl)piperazines from aromatic olefins and 1-arylpiperazines
US6313297A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 13, 2000 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | Jul 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/096
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a 1-aryl-4-(arylethyl)piperazine of the formula (I) ##STR1## by reacting a 1-arylpiperazine of the formula (II) ##STR2## with an aromatic olefin of the formula (III) EQU Ar'CR.sup.1.dbd.CHR.sup.2 (III) in an inert solvent in the presence of at least one basic catalyst, where in the formulae (I) to (III) PA1 Ar and Ar' independently of one another are an aryl radical, selected from the group of the fused and unfused C.sub.6 -C.sub.22 -aromatics and the fused or unfused C.sub.5 -C.sub.22 -heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring; and PA1 R.sub.1 and R.sub.2 independently of one another are a hydrogen atom, a C.sub.1 -C.sub.8 -alkyl radical or an aryl radical Ar.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.