Process for the preparation of pyridine derivatives
US6313303A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 3, 2000 |
| Grant date | Nov 6, 2001 |
| Priority date | — |
| Expiry date | Jan 3, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R.sup.1 is hydrogen, methoxy or difluoromethoxy; R.sup.2 is methyl or methoxy; R.sup.3 is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R.sup.4 is hydrogen or methyl ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.