Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings

US6313307A · kind A · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Michael Ennis · Mattawan, US
• Robert Louis Hoffman · Kalamazoo, US
• Douglas K. Hutchinson · Antioch, US
• David Anderson · Kalamazoo, US
• Toni-Jo Poel · Pinckney, US
• Richard C. Thomas · Kalamazoo, US

Key dates

• Filing date: Mar 3, 2000
• Grant date: Nov 6, 2001
• Expiry date: Mar 3, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing a compound of the formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein X is --NR.sub.1 --, --S(O).sub.g --, or --O--; R.sub.1 is --H, C.sub.1-6 alkyl optionally substituted with one or more --OH, --CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, --COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i -Het; R.sub.2 is --H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are the same or different and are --H or halo; R.sub.6 is --H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy. The compounds are useful antimicrobial agents.