4-thionaphthyl--1H--imidazoles which are useful.alpha.22-adrenoceptoR agonists/ antagonists

US6313309A · kind A · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Ellen W. Baxter · Glenside, US
• Robert E. Boyd · Horsham, US
• Michelle Jetter · Norristown, US
• Mark McDonnell · Lansdale, US
• Allen B. Reitz · Lansdale, US
• Tina Morgan Ross · Limerick, US

Key dates

• Filing date: Apr 5, 1999
• Grant date: Nov 6, 2001
• Expiry date: Apr 5, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

4-thionaphthyl-1H-imidazoles are .alpha..sub.2 -adrenoceptor agonists/antagonists. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful agents to treat hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, the need for anesthesia or cardiac arrythmia.