Transdermal therapeutic plaster

US6315854A · kind A · utility

Assignee

• LTS Lohmann Therapie-Systeme GmbH Co. KG · DE

Inventors

• Dieter Anhauser · Melsbach, DE
• Lothar Deurer · Koblenz, DE
• Thomas Hille · Neuwied, DE
• Peter Steinborn · Neuwied, DE

Key dates

• Filing date: Sep 22, 1995
• Grant date: Nov 13, 2001
• Expiry date: Sep 22, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T156/1095
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance from their outer dimensions; the the resulting lattice-type refuse of the drug-free pressure-sensitive adhesive backing layer (1) is removed; and subsequently the protective laye…