Rapidly disintegrating solid oral dosage form

US6316029A · kind A · utility

Assignee

• Flak Pharma International, Ltd.

Inventors

• Rajeev Jain · Framingham, US
• Stephen B. Ruddy · Schwenksville, US
• Kenneth Iain Cumming · Dublin, IE
• Maurice Joseph Anthony Clancy · Celbridge, IE
• Janet Elizabeth Codd · Athlone, IE

Key dates

• Filing date: May 18, 2000
• Grant date: Nov 13, 2001
• Expiry date: May 18, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/906
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a rapidly disintegrating solid oral dosage form of a poorly soluble active ingredient and at least one pharmaceutically acceptable water-soluble or water-dispersible excipient, wherein the poorly soluble active ingredient particles have an average diameter, prior to inclusion in the dosage form, of less than about 2000 nm. The dosage form of the invention has the advantage of combining rapid presentation and rapid dissolution of the active ingredient in the oral cavity.