Efficient synthesis of nucleosides
US6316228A · kind A · utility
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23Claims
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Key dates
| Filing date | Jul 12, 1999 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Jul 12, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/832
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions, including cell cultures, for producing nucleosides are provided which comprise contacting a nucleoside precursor and a sugar moiety donor with a cell containing a nucleoside phosphorylase. The nucleoside precursor can be a purine or pyrimidine base and the sugar moiety donor can comprise a ribose, a deoxyribose, including 2-deoxyribose, or other sugar of choice. The methods and composition can be used to make thymidine from thymine and 2-deoxyinosine or 2'-deoxyadenosine. Other nucleosides, including those having anticancer and/or antiviral properties, also can be obtained according to the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.