Cyclosporin a conjugates and uses therefor
US6316405A · kind A · utility
11Cited by
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13Claims
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Key dates
| Filing date | Feb 22, 1999 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Feb 22, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are conjugates of A.beta.-binding peptides and CsA analogs and conjugates of A.beta.-binding peptides and FK506 Binding Peptide inhibitors. These conjugates chemically induce dimerization of either cyclophilin or FK506 Binding Peptide with A.beta. peptide, a major component of amyloid plaques found in neurological disorders such as Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis. The conjugates are useful in the treatment of neurological diseases involving the formation of amyloid plaques because they inhibit and/or prevent the aggregation and deposition of A.beta. peptide into plaques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.