Regulated apoptosis

US6316418A · kind A · utility

Assignees

• Board of Trustees of the Leland Stanford Junior University · US
• President and Fellows of Harvard College · US

Inventors

• Gerald R. Crabtree · Woodside, US
• Stuart L. Schreiber · Cambridge, US
• David Spencer · Houston, US
• Thomas J. Wandless · Cambridge, US
• Peter Belshaw · Madison, US
• Steffan N. Ho · San Diego, US

Key dates

• Filing date: Apr 30, 1999
• Grant date: Nov 13, 2001
• Expiry date: Apr 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.