Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
US6316487A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2000 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Oct 6, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject invention pertains to novel compounds, and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns a method of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. The new compounds can have particular utility for treating life-threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The product can also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.