Radicicol derivatives
US6316491A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 1998 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Jun 24, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D313/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R.sup.3 represents Y--R.sup.5 (wherein Y represents substituted or unsubstituted alkylene; and R.sup.5 represents CONR.sup.6 R.sup.7 (wherein R.sup.6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R.sup.7 represents hydroxyl, substituted lower alkyl, and the like), CO.sub.2 R.sup.12 (wherein R.sup.12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the like) and the like; X represents halogen or is combined together with R.sup.4 to represent a single bond; and R.sup.4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.