Process for the preparation of enzymatically degradable polymers
US6316585A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 19, 2000 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Jan 19, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G69/44
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
The present invention relates to the preparation of enzymatically degradable polymers, having repeating structural unit as shown hereinbelow: ##STR1## PA1 X--is selected from phenolic --OH of tyrosine, --OH of serine and threonine and --SH of cysteine PA1 Y--is pendant group selected from drug molecules containing carboxyl groups, PA1 R--is hydrogen, methyl or mixture of hydrogen and methyl on the individual molecule, PA1 n--is an integer from 0 to about 100, and PA1 m--is an integer from 0 to 10, the said process comprises the steps of reacting diester of poly (oxyalkylene glycol) and hydrochloride of trifunctional amino acid with a dicarboxylic acid in the presence of a condensing agent in a solvent at a temperature in the range of 0.degree. C. to room temperature for a period ranging between 1 hr to 24 hrs, neutralizing the hydrochloride salt by base, and reacting the free amino groups in the side chain of the polymer with the drug molecule containing carboxyl groups to obtain enzymatically degradable polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.