Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis
US6316613A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 25, 1997 |
| Grant date | Nov 13, 2001 |
| Priority date | — |
| Expiry date | Jul 25, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31971
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated .alpha.-, .beta.-, and .gamma.-cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of sulfation and narrower heterogeneity than previous cyclodextrin derivatives. CE analyses using highly sulfated cyclodextrins produce improved resolution of a wide variety of chiral drugs, particulaly neutral compounds and amines. The highly sulfated .alpha.-,.beta.-, and .gamma.-cyclodextrins produce separations which complement each other to further expand the number of neutral and basic drugs that can be resolved by capillary electrophorsis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.