Synthesis of epothilones, intermediates thereto and analogues thereof

US6316630A · kind A · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• Samuel J. Danishefsky · New Haven, US
• Peter Bertinato · Old Lyme, US
• Dai-Shi Su · New York, US
• Dongfang Meng · Morganville, US
• Ting-Chao Chou · Paramus, US
• Ted Kamenecka · New York, US
• Erik Sorensen · Village of La Jolla, US
• Aaron Balog · Lambertville, US
• Kenneth A. Savin · New York, US

Key dates

• Filing date: Jun 6, 2000
• Grant date: Nov 13, 2001
• Expiry date: Jun 6, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1892
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.