Method for producing small-particle preparations of biologically active substances

US6318650A · kind A · utility

Assignee

• BASF SE

Inventors

• Jorg Breitenbach · Mannheim, DE
• Hans D. Zettler · Havelsee, DE

Key dates

• Filing date: Nov 15, 1999
• Grant date: Nov 20, 2001
• Expiry date: Nov 15, 2019

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29K2105/0035
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder divided into a plurality of zones, wherein there is firstly melting of the matrix auxiliaries and mixing of the bioactive components with the matrix auxiliaries in a heatable zone, after which the mixture is cooled, precomminuted and finely ground in a cooling zone, the screw geometry in the cooling zone being selected so that the cooling zone consists of a conveying zone, a mixing zone and a kneading zone.