Inhibition of abnormal cell growth with corticotropin-releasing hormone analogs
US6319900A · kind A · utility
4Cited by
4References
17Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Sep 21, 1999 |
| Grant date | Nov 20, 2001 |
| Priority date | — |
| Expiry date | Sep 21, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The glutamic acid residue of corticotropin-releasing hormone analogs have had the position 20 amino acid residue replaced with a D-amino acid moiety. The resulting CRH analogs do not significantly lower blood pressure but have anti-proliferative actions in cell culture and inhibit experimental cancer growth in animals (mice and rats). Novel applications of such analogs are described, such as to inhibit abnormal cell proliferation for conditions such as cancer, including melanoma, and for inflammatory dermatoses, such as psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.