Use of MEK1 inhibitors as protective agents against damage due to ischemia

US6319955A · kind A · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Alessandro Alessandrini · Cambridge, US
• Joseph Bonventre · Wayland, US
• Michael A. Moskowitz · Belmont, US
• Shobu Namura · Osaka, JP

Key dates

• Filing date: Oct 6, 2000
• Grant date: Nov 20, 2001
• Expiry date: Oct 6, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of MEK1 inhibitors to reduce tissue damage resulting from ischemia and/or reperfusion, particularly brain damage associated with ischemia resulting from stroke. Pharmaceutical compositions, kits and perfusion fluids including MEK1 inhibitors are also provided.