Process for the reduction of oxiranyl epothilones to olefinic epothilones
US6320045A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 1999 |
| Grant date | Nov 20, 2001 |
| Priority date | — |
| Expiry date | May 21, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention as claimed is directed to a process for making an epothilone having the following structures ##STR1## from ones having an oxiranyl moiety, by reacting a compound having the latter structure with a metal or metal-assisted reagent. Said metal or metal-assisted reagent is selected from the group consisting of a) reactive metallocenes; b) [N.sub.2 C(CO.sub.2 Me).sub.2, cat Rh.sub.2,(OAC).sub.4 ]; c) [N.sub.2 C(CO.sub.2 Me).sub.2, cat[(n-C.sub.7 H.sub.15 CO.sub.2).sub.2 Rh].sub.2 ]; d) [Zn--Cu, EtOH]; e) [Mg(Hg), MgBr]; f) Cr; g) [FeCl.sub.3, n-BuLi]; h) [TiCl.sub.3, LiAlH.sub.4 ]; i) [TiCl.sub.4, Zn]; j) [WCl.sub.6, LiAlH.sub.4,]; k) [NbCl.sub.5, NaAlH.sub.4 ]; l) [VCl.sub.3,Zn] and m) [WCl.sub.6, n-BuLi].
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.