Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same

US6322797A · kind A · utility

Assignees

• Guilford Pharmaceuticals, Inc. · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Hai-Quan Mao · Singapore, SG
• Kam W. Leong · Ellicott City, US
• Wenbin Dang · Baltimore, US
• Hungnan Lo · Shaker Heights, US
• Zhong Zhao · Munich, DE
• David P. Nowotnik · Kingsville, US
• James P. English · Birmingham, US

Key dates

• Filing date: Apr 2, 1998
• Grant date: Nov 27, 2001
• Expiry date: Apr 2, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T442/3545
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: ##STR1## wherein R is a divalent organic moiety; PA1 R' is an aliphatic, aromatic or heterocyclic residue; PA1 x is .gtoreq.1; and PA1 n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.