Variant human .alpha.7 acetylcholine receptor subunit, and methods of production and uses thereof
US6323000A · kind A · utility
25Cited by
1References
20Claims
0Family size
Inventors
Key dates
| Filing date | Dec 20, 1996 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Dec 20, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A variant human .alpha.7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human .alpha.7 nAChR. Nucleic acid molecules encoding the variant human .alpha.7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.