Microcapillary-based flow-through immunosensor and displacement immunoassay using the same
US6323042A · kind A · utility
14Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1999 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Nov 8, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A displacement-type flow immunoassay is performed using a microcapillary passage. The inner wall of the microcapillary passage has immobilized thereon antibodies to the antigen of interest. Labeled antigen is immunologically bound to the immobilized antibodies. Sample antigen passing through the column displaces the labeled antigen. Downstream, the displaced labeled antigen is detected. The microcapillary format of the present invention enhances the sensitivity of the immunoassay over the sensitivity of displacement-type flow immunoassays performed in a column at similar flow rates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.