Estrogen mimetics lacking reproductive tract effects
US6323190A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 28, 1999 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Jul 28, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/386
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) ##STR1## wherein R.sub.1 is --O(CH.sub.2).sub.m R.sub.3 or --(CH.sub.2).sub.n R.sub.3 ; wherein R.sub.3 is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R.sub.2 is either H or --OH. Each of R.sub.1 and R.sub.2 can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R.sub.1 is --O(CH.sub.2).sub.m R.sub.3 or --(CH.sub.2).sub.n R.sub.3 ; R.sub.3 is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R.sub.2 is H or --OH; and wherein each of R.sub.1 and R.sub.2 is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R.sub.2 is not para --OH when m is 1 and R.sub.3 is --COOH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.