Prostaglandin compositions and methods of treatment for male erectile dysfunction
US6323241A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 10, 2000 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Jan 10, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/36
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E.sub.1 composition of a semi-solid consistency. The composition comprises prostaglandin E.sub.1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C.sub.1 to C.sub.8 alcohol, an aliphatic C.sub.8 to C.sub.30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.