Dolastatin peptides

US6323315A · kind A · utility

Assignees

• BASF SE
• THE ARIZONA BOARD OF REGENTS · US

Inventors

• George R. Pettit · Paradise Valley, US
• Jayaram K. Srirangam · San Diego, US
• Michael D. Williams · New Baltimore, US
• Kieran Durkin · Folsom, US
• Teresa Barlozzari · Wellesley, US
• Andreas Kling · Mannheim, DE
• Bernd Janssen · Ludwigshafen, DE
• Andreas Haupt · Ludwigshafen, DE

Key dates

• Filing date: Mar 31, 2000
• Grant date: Nov 27, 2001
• Expiry date: Mar 31, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of the formula ##STR1## where R.sub.1 -R.sub.5 are each, independently, a hydrogen atom or a normal or branched C.sub.1 -C.sub.6 -alkyl group; A is a methionyl, phenylalanyl or phenylglycyl residue; n is 0 or 1; R.sub.6 is a hydrogen atom; and R.sub.7 is a carbocylic group, an aromatic group, a C.sub.1 -C.sub.4 -alkyl group, a pyridylalkyl group or a heterocyclic group. In another embodiment, R.sub.6 is benzyl or --C(O)OR.sub.8, where R.sub.8 is a C.sub.1 -C.sub.6 -alkyl group, and R.sub.7 is a heteroaromatic group, such as a 2-thiazolyl group.