Therapeutic and diagnostics proteins comprising a SOCS box

US6323317A · kind A · utility

Assignee

• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• Douglas Hilton · Melbourne, AU
• Warren Alexander · Melbourne, AU
• Elizabeth M. Viney · Melbourne, AU
• Tracy Willson · Melbourne, AU
• Rachael T. Richardson · Melbourne, AU
• Robyn Starr · Melbourne, AU
• Sandra E. Nicholson · Mona Vale, AU
• Donald Metcalf · Melbourne, AU
• Nicos A. Nicola · Melbourne, AU

Key dates

• Filing date: Apr 30, 1999
• Grant date: Nov 27, 2001
• Expiry date: Apr 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as other mediators of signal transduction such as endogenous or exogenous molecules, antigens, microbes and microbial products, viruses or components thereof, ions, hormones and parasites.