Ligand-binding, dimerized polypeptide fusions
US6323323A · kind A · utility
116Cited by
21References
10Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 25, 1999 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | Oct 25, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Ligand-binding, dimerized polypeptide fusions comprising two polypeptide chains are disclosed. Each of the polypeptide chains comprises a ligand-binding domain of either a growth factor receptor or a hormone receptor joined to an immunoglobulin constant region polypeptide. Dimerization of the polypeptide fusion results in enhancement of biological activity. The immunoglobulin constant region polypeptide may comprise an immunoglobulin heavy chain constant region domain and hinge region.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.