Process for preparing probucol derivatives
US6323359A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 2, 2000 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | May 2, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C319/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is described for the preparation of water-soluble derivatives of probucol compounds having the following formula ##STR1## PA1 where R.sub.1 and R.sub.2 are the same or different and are alkyl, alkenyl or aryl having from 1 to 8 carbon atoms, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are the same or different and are alkyl having from 1 to 4 carbon atoms and X and Y are the same or different and are hydrogen or the groups saturated acyl or unsaturated acyl having from 1 to 8 carbon atoms said saturated or unsaturated acyl groups containing a polar or charged functionality. The method for preparation of such compounds comprises reacting a solution of a probucol compound having the following formula ##STR2## PA1 where R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as previously defined with a compound selected from the group where R.sub.1 and R.sub.2 are methyl, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are tert-butyl and X is H or the group --C(O)--(CH.sub.2).sub.2 --C(O)OH and Y is the group --C(O)--(CH.sub.2).sub.2 --C(O)OH comprising reacting a solution of a probucol compound having the following formula ##STR3## PA1 where R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as previously define…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.