Ion mobility and mass spectrometer
US6323482A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 17, 1999 |
| Grant date | Nov 27, 2001 |
| Priority date | — |
| Expiry date | May 17, 2019 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/42
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An ion mobility and mass spectrometer instrument includes an ion source region coupled to an ion mobility spectrometer having an ion outlet coupled to a quadrupole mass filter. An output of the filter is coupled to a collision cell which has an ion outlet coupled to an ion acceleration region of a mass spectrometer such as a time of flight mass spectrometer. The instrument is particularly well suited for sequencing analysis wherein a sample is ionized and a resulting three-dimensional ion spectrum (ion intensity vs. ion mobility and ion mass) is observed. If the spectrum reveals that no ions overlap in mobility values, the collision cell is filled with a suitable buffer gas and the instrument is reactivated whereby a complete three-dimensional spectrum of parent and daughter ions results. If, however, the original spectrum reveals that two or more ions overlap in ion mobility values, the collision cell is filled with a buffer gas and the quadrupole mass filter is controlled to selectively filter out all but one of the ions having overlapping mobility values. The instrument is reactivated, and the quadrupole mass filter is selectively controlled, as many times as mobility overlap oc…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.