Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases
US6326393A · kind A · utility
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16Claims
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Key dates
| Filing date | Jun 20, 2000 |
| Grant date | Dec 4, 2001 |
| Priority date | — |
| Expiry date | Jun 20, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is an dialkoxyphosphonate, or .alpha.-hydroxyamide group and Z is an acyl or .alpha.-ketocarbamate functionality. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid support, are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.