Glucose and lipid lowering compounds

US6326396A · kind A · utility

Assignee

• Alteon, Inc. · US

Inventors

• Dilip Wagle · Valley Cottage, US
• Sheng Fang · Mahwah, US
• Ihor Terleckyj · Ridgewood, US
• John Resek · Brooklyn, US
• John J. Egan · New York, US

Key dates

• Filing date: Nov 12, 1999
• Grant date: Dec 4, 2001
• Expiry date: Nov 12, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dotted line between carbon 4 and R.sup.2, and the dotted line between carbon 11 and R.sup.3 each independently represent an optional double bond from the respective numbered carbon to a linked carbon, and wherein X is hydroxy or, together with Y is oxy linking carbon 8 and carbon 12.