Imidazole derivatives for blocking the release of arachidonic acid from phospholipids
US6326500A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 27, 2000 |
| Grant date | Dec 4, 2001 |
| Priority date | — |
| Expiry date | Dec 27, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I) ##STR1## and salts thereof, wherein PA1 R.sub.1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR.sub.13 R.sub.14, --N(R.sub.15)SO.sub.2 R.sub.16, haloalkoxy, haloalkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, --SO.sub.n R.sub.7, alkoxycarbonylalkyl, carboxylalkyl, --CONR.sub.11 R.sub.12, carbamoylvinyl, --O--SO.sub.2 R.sub.21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl, --NR.sub.60 R.sub.61 or --(O).sub.z --L.sub.3 --G (G=-NR.sub.22 R.sub.23, --SO.sub.m R.sub.26, CONR.sub.27 R.sub.28 or --OR.sub.29); PA1 R.sub.2 and R.sub.3 are independently hydrogen halo, alkyl, alkoxy, --NR.sub.13 R.sub.14, haloalkoxy, haloalkyl, hydroxy, --SO.sub.n R.sub.7 or --NR.sub.60 R.sub.61 ; PA1 L.sub.1 is a bond, alkylene, cycloalkylene or cycloalkylidene; PA1 T is a bond, O, S, SO, SO.sub.2, CO or 1,3-dioxolan-2-ylidene; PA1 L.sub.2 is alkylene, cycloalkylene or cycloalkylidene; PA1 R.sub.6 is hydrogen or alkyl; PA1 Q is alkylene; and PA1 Y is imidazolyl, which are antiinflammatory, antiallergic and immunodulant agents. Compositions containing these compounds and processes to make them are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.