Method of producing an optically active .beta.-hydroxy sulfonic acid compound by catalytic asymmetric hydrogenation
US6326512A · kind A · utility
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8Claims
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Key dates
| Filing date | Jun 1, 2000 |
| Grant date | Dec 4, 2001 |
| Priority date | — |
| Expiry date | Jun 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C303/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method of producing an optically active .beta.-hydroxy sulfonic acid compound comprising hydrogenating a .beta.-keto sulfonic acid compound represented by formula 1: ##STR1## where R.sup.1 represents an alkyl or a phenyl group, which may be substituted, and R.sup.2 represents sodium or an alkyl group, in an acidic solvent, in the presence of an asymmetric catalyst comprising a complex of bivalent Ru, having 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl as a ligand, to produce a compound represented by formula 2: ##STR2## where R.sup.1 and R.sup.2 are as defined above, and * designates an asymmetric carbon atom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.