Prosthetic grafts

US6328762A · kind A · utility

Assignee

• Sulzer Biologics, Inc. · US

Inventors

• Diane Lee Anderson · Dripping Springs, US
• John Ranieri · Austin, US
• Maurizio Capogrossi Colognesi · Roma, IT
• Marco Scoccianti · Roma, IT
• Antonio Facchiano · Roma, IT

Key dates

• Filing date: Apr 27, 1999
• Grant date: Dec 11, 2001
• Expiry date: Apr 27, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant and adherent cells adhered to the outer surface of the implant. The adherent cells are transfected with at least one recombinant nucleic acid molecule encoding at least one protein that enhances patency of the graft. The prosthetic graft has a long-term patency and success rate that is superior to other previously described prosthetic grafts designed for such use. Also disclosed are methods of making and using such a graft.