Patent · US Expired

Assays for detecting .beta.-secretase inhibition

US6329163A · kind A · utility

36Cited by

2References

15Claims

0Family size

Assignee

Elan Pharmaceuticals, Inc. · US

Inventors

John P. Anderson · Langenfeld, DE
Kirsten L. Jacobson-Croak · San Bruno, US
Sukanto Sinha · San Francisco, US

Key dates

Filing date	Apr 2, 1998
Grant date	Dec 11, 2001
Priority date	—
Expiry date	Apr 2, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Compositions comprising a novel protease capable of cleaving .beta.-amyloid precursor protein on the amino-terminal side of the .beta.-amyloid peptide therein are provided. The protease is designated .beta.-secretase. The .beta.-secretase may be used in screening assays to identify .beta.-secretase inhibitors, or the .beta.-secretase is combined with a suitable polypeptide substrate and cleavage of the substrate determined in the presence and absence of the test substance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.