Helper functions for recombinant vector production
US6329181A · kind A · utility
23Cited by
7References
45Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2000 |
| Grant date | Dec 11, 2001 |
| Priority date | — |
| Expiry date | Aug 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for preparations of recombinant parvovirus virions with a reduced number of replication competent particles. The compositions of the present invention include nucleic acids encoding parvovirus helper functions which contain at least one non-native intron sequence. The present invention also includes helper function vectors, host cells transfected with the helper function vectors, methods of using the helper function vectors, and recombinant parvovirus virions produced by such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.